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OCR: ced, pure Once isolated peptides have been sequer ministered synthetic peptide can be produced and a by intravenous infusion to determine it ne physiological role as a circulating horm release or Gastrointestinal actions such as enzyme dilatation, motility, or systemic effects such as vaso found onlymay be seen. Such effects are sometimes ggesting at markedly supraphysiological doses, su a.s that the peptides may be most importan inal paracrine agents, controlling gastrointes uch higher function locally where they will reach n encentrations than in the circulation